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To investigate the influence of IKK2 inhibitor VIII (HY-13060, Medchem Specific, Monmouth Junction, NJ) on OA development, MLI surgeries had been performed in 12-7 days-outdated C57BL/6 WT mice. The mice had been injected with IKK2 inhibitor VIII (two mg/kg, IP) every single alternate day for 5 months. OARSI scoring was executed by blinded review

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